Effect of opioid antagonist naloxone on maternal motivation in albino rats

We studied the effect of nonselective antagonist of opioid receptor naloxone on the behavior of albino female rats on days 4-6 after delivery. Intraperitoneal injection of naloxone (5 mg/kg) significantly stimulated maternal reactions (increased the number of approaches to pups, decreased the latenc...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 140; no. 1; pp. 10 - 12
Main Authors Dobryakova, Yu V, Dubynin, V A, Ivleva, Yu A, Belyaeva, Yu A, Kamenskii, A A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.07.2005
Subjects
Animals
Female
Maternal Behavior - drug effects
Motivation
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
Rats
Rats, Mutant Strains
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Summary:We studied the effect of nonselective antagonist of opioid receptor naloxone on the behavior of albino female rats on days 4-6 after delivery. Intraperitoneal injection of naloxone (5 mg/kg) significantly stimulated maternal reactions (increased the number of approaches to pups, decreased the latency of their transfer into new location). Intranasal naloxone (1 mg/kg) produced similar changes. Naloxone in intraperitoneal dose of 1 mg/kg and intranasal dose of 0.2 mg/kg virtually did not modify maternal behavior.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0398-8