Effect of administration of lead nitrate to pregnant rats on the lungs in their offspring

Lead nitrate in a dose of 200 mg/kg was administered to female rats via a gartric tube on days 5 and 12 of pregnancy. The lungs of their offspring were examined on day 40 of life. We found a decrease in the ratio between the specific volumes of alveolar lumens and interalveolar septa and hypertrophy...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 139; no. 6; pp. 655 - 657
Main Authors Lebed'ko, O A, Ryzhavskii, B Ya
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.06.2005
Subjects
Animals
Female
Lead - administration & dosage
Lead - toxicity
Lung - drug effects
Lung - metabolism
Lung - physiology
Lung Diseases - chemically induced
Lung Diseases - metabolism
Lung Diseases - pathology
Lung Diseases - physiopathology
Lung Volume Measurements
Nitrates - administration & dosage
Nitrates - toxicity
Oxidation-Reduction
Pregnancy
Prenatal Exposure Delayed Effects
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - metabolism
Rats
Reactive Oxygen Species - metabolism
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Summary:Lead nitrate in a dose of 200 mg/kg was administered to female rats via a gartric tube on days 5 and 12 of pregnancy. The lungs of their offspring were examined on day 40 of life. We found a decrease in the ratio between the specific volumes of alveolar lumens and interalveolar septa and hypertrophy of lymphoid tissue in the bronchial wall (compared to the offspring of intact females). Chemiluminescent analysis revealed activation of lipid peroxidation and decrease in antioxidant antiradical activity of the lungs.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0369-0