Effects of Mannosylerythritol-Lipids-B on Cutibacterium acnes ATCC 6919

• Published in: Indian journal of microbiology Vol. 64; no. 1; pp. 225 - 228
• Main Authors: Coelho, Ana L. S., Laroque, Denise A., Feuser, Paulo E., de Andrade, Cristiano J., Carciofi, Bruno A. M., de Oliveira, Débora
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.03.2024; Springer Nature B.V
• Subjects: Acne; Antimicrobial activity; Bacteria; Biomedical and Life Sciences; Cutibacterium acnes; Dilution; Glycolipids; Gram-positive bacteria; Life Sciences; Lipids; Medical Microbiology; Membranes; Microbiology; Microorganisms; Original Research Article; Spectrophotometry; Acne vulgaris; Antimicrobial; Skin microbiome; Glycolipid
• ISSN: 0046-8991; 0973-7715
• DOI: 10.1007/s12088-023-01169-3

Mannosylerythritol-lipids-B (MEL-B) are microbial-produced glycolipids with skincare properties, notably moisturizing, antimelanogenic, antimicrobial, and antiaging. Thus, there is a potential use of MEL-B in a formulation for treating acne-prone skin. This study investigated the antimicrobial effect of MEL-B against the Gram-positive bacteria Cutibacterium acnes . The broth macro dilution method was used to evaluate the growth of C. acnes (3–4 CFU/mL), in the absence (positive control) or presence of MEL-B (128, 192, 256, and 512 μg/mL). Additionally, the leakage of genetic materials was used to determine the potential drug-induced membrane disruption of glycolipids. The amount of DNA and RNA release was quantified spectrophotometrically at 260 nm. Macro dilution technique and membrane integrity experiments showed that MEL-B does not have antimicrobial activity against C. acnes. Indeed, MEL-B assisted C. acnes growth. Ultimately, MEL-B has been reported as a remarkably active compound for skincare formulations; however, preliminarily, it should be avoided for acneic skin.