Preparation of hydroxypropyl methyl cellulose phthalate nanoparticles with mixed solvent using supercritical antisolvent process and its application in co-precipitation of insulin

To obtain hydroxypropyl methyl cellulose phthalate (HPMCP)/insulin nanospheres by supercritical antisolvent process, the formation of HPMCP nanoparticles was first investigated. The effects of ratio of the mixed solvent, pressure, temperature, concentration, flow rate of CO2 and solution on forming...

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Published inAdvanced powder technology : the international journal of the Society of Powder Technology, Japan Vol. 23; no. 2; pp. 157 - 163
Main Authors Jin, He Yang, Xia, Fei, Zhao, Ya Ping
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2012
Subjects
HPMCP
Insulin
Mixed solvent
Nanoparticle
SAS process
SAS process
Mixed solvent
Nanoparticle
Insulin
HPMCP
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Summary:To obtain hydroxypropyl methyl cellulose phthalate (HPMCP)/insulin nanospheres by supercritical antisolvent process, the formation of HPMCP nanoparticles was first investigated. The effects of ratio of the mixed solvent, pressure, temperature, concentration, flow rate of CO2 and solution on forming HPMCP nanoparticles are discussed. It was found that different morphologies of HPMCP could be produced by varying the ratio of DMSO to acetone in the solvent. The operating parameters were optimized for making HPMCP nanoparticles. Formation of HPMCP/insulin nanospheres was further inspected. The nanospheres with the size ranging from 138nm to 342nm were obtained. The loading of insulin in the nanospheres ranged from 10.76% to 16.04% and the encapsulation efficiency reached 100%. The release of insulin is also discussed.
ISSN:0921-8831
1568-5527
DOI:10.1016/j.apt.2011.01.007