Intraoperative frozen section in gynaecology cancers with special reference to ovarian tumours: time to “unfreeze” the pitfalls in the path of the Derby horse of Oncology
Purpose In an oncological set up the role of frozen section biopsy is undeniable. They serve as an important tool for surgeon’s intraoperative decision making but the diagnostic reliability of intraoperative frozen section may vary from institute to institute. The surgeon should be well aware of the...
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Published in | Journal of cancer research and clinical oncology Vol. 149; no. 12; pp. 9767 - 9775 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.09.2023
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
In an oncological set up the role of frozen section biopsy is undeniable. They serve as an important tool for surgeon’s intraoperative decision making but the diagnostic reliability of intraoperative frozen section may vary from institute to institute. The surgeon should be well aware of the accuracy of the frozen section reports in their setup to enable them to take decisions based on the report. This is why we had conducted a retrospective study at Dr B. Borooah Cancer Institute, Guwahati, Assam, India to find out our institutional frozen section accuracy.
Methods
The study was conducted from 1st January 2017 to 31st December 2022 (5 years). All gynaecology oncology patients who were operated on during the study period and had an intraoperative frozen section done were included in the study. Patients who had incomplete final histopathological report (HPR) or no final HPR were excluded from the study. Frozen section and final histopathology report were compared and analysed and discordant cases were analysed based on the degree of discordancy.
Results
For benign ovarian disease, the IFS accuracy, sensitivity and specificity are 96.7%, 100% and 93%, respectively. For borderline ovarian disease the IFS accuracy, sensitivity and specificity are 96.7%, 80% and 97.6%, respectively. For malignant ovarian disease the IFS accuracy, sensitivity and specificity are 95.4%, 89.1% and 100%, respectively. Sampling error was the most common cause of discordancy.
Conclusion
Intraoperative frozen section may not have 100% diagnostic accuracy but still it is the running horse of our oncological institute. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0171-5216 1432-1335 |
DOI: | 10.1007/s00432-023-04866-0 |