The Expression of Markers of Acute Kidney Injury Kim1 and NGAL after Administration of High Doses of Lithium Carbonate in Mice with Engrafted Skin Melanoma B16

• Published in: Bulletin of experimental biology and medicine Vol. 176; no. 5; pp. 567 - 571
• Main Authors: Taskaeva, Yu. S., Kasatova, A. I., Shatruk, A. Yu, Taskaev, S. Yu, Bgatova, N. P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2024; Springer Nature B.V
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - metabolism; Animals; Biochemistry; Biomarkers - blood; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Biophysics; Boron; Cell Biology; Cellular biology; Clinical trials; Cloning; Drug dosages; Gelatinase; Hepatitis A Virus Cellular Receptor 1 - metabolism; Internal Medicine; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidneys; Laboratory Medicine; Leukocytes (neutrophilic); Lipocalin; Lipocalin-2 - metabolism; Lithium; Lithium Carbonate - administration & dosage; Male; Melanoma; Melanoma, Experimental - drug therapy; Melanoma, Experimental - metabolism; Melanoma, Experimental - pathology; Mice; Neutrons; Neutrophils; Pathology; Proteins; Renal function; Skin cancer; Skin Neoplasms - drug therapy; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; NGAL; Kim1; acute kidney injury; neutron capture therapy; lithium carbonate
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-024-06068-1

The expression of marker proteins of acute kidney injury after administration of high doses of lithium carbonate was assessed to evaluate the possibility of lithium use in neutron capture therapy. In mice with implanted skin melanoma B16, the expression of Kim1 (kidney injury molecule 1) and NGAL (neutrophil gelatinase-associated lipocalin) proteins in the kidneys was evaluated immunohistochemically 15, 30, 90, 180 min, and 7 days after peroral administration of lithium carbonate at single doses of 300 and 400 mg/kg. An increase in the expression of the studied proteins was found in 30 and 90 min after administration of 400 mg/kg lithium carbonate, however, 7 days after the drug administration, the expression returned to the level observed in the control group. It can be suggested that single administration of lithium carbonate in the studied doses effective for lithium neutron capture therapy will not significantly affect the renal function.