Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation

• Published in: Clinical & experimental metastasis Vol. 41; no. 1; pp. 9 - 24
• Main Authors: Nair, Sachin G, Benny, Sonu, Jose, Wesley M, Aneesh T P
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2024; Springer Nature B.V
• Subjects: Adrenergic beta-Antagonists - pharmacology; Adrenergic beta-Antagonists - therapeutic use; Angiogenesis; Antihypertensive Agents - adverse effects; Antihypertensives; Apoptosis; Beta blockers; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cancer therapies; Chemotherapy; Hematology; Humans; Hypertension; Hypertension - drug therapy; Hypertension - epidemiology; Metastases; Metastasis; Oncology; Patients; Prognosis; Review; Surgical Oncology; Hypertension; Cardio-oncology; Angiogenesis; Metastasis; Beta blockers; Apoptosis
• ISSN: 0262-0898; 1573-7276
• DOI: 10.1007/s10585-023-10258-y

The prevailing treatment stratagem in cancer therapy still challenges the dilemma of a probable metastatic spread following an initial diagnosis. Including an anti-metastatic agent demands a significant focus to overrule the incidence of treatment failures. Adrenergic stimulation underlying the metastatic spread paved the way for beta blockers as a breakthrough in repurposing as an anti-metastatic agent. However, the current treatment approach fails to fully harness the versatile potential of the drug in inhibiting probable metastasis. The beta blockers were seen to show a myriad of grip over the pro-metastatic and prognostic parameters of the patient. Novel interventions in immune therapy, onco-hypertension, surgery-induced stress, induction of apoptosis and angiogenesis inhibition have been used as evidence to interpret our objective of discussing the potential adjuvant role of the drug in the existing anti-cancer regimens. Adding weight to the relative incidence of onco-hypertension as an unavoidable side effect from chemotherapy, the slot for an anti-hypertensive agent is necessitated, and we try to suggest beta-blockers to fill this position. However, pointing out the paucity in the clinical study, we aim to review the current status of beta blockers under this interest to state how the drug should be included as a drug of choice in every patient undergoing cancer treatment.