18β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model

• Published in: Environmental toxicology and pharmacology Vol. 52; pp. 99 - 113
• Main Authors: Kim, Seung-Hyung, Hong, Jung-hee, Lee, Ji-Eun, Lee, Young-Cheol
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017
• Subjects: 18β-glycyrrhetinic acid; Allergens; Animals; Anti-Asthmatic Agents - pharmacology; Anti-Asthmatic Agents - therapeutic use; Asthma; Asthma - blood; Asthma - drug therapy; Asthma - immunology; Asthma - pathology; Bronchoalveolar Lavage Fluid - cytology; Bronchoalveolar Lavage Fluid - immunology; Cell Count; Cell Line; Cell Survival - drug effects; Cytokines - immunology; Emergency; Fabaceae; Female; Forkhead Transcription Factors - immunology; Foxp3; GATA-3; GATA3 Transcription Factor - immunology; Glycyrrhetinic Acid - analogs & derivatives; Glycyrrhetinic Acid - pharmacology; Glycyrrhetinic Acid - therapeutic use; IL-13; IL-5; Immunoglobulin E - blood; Lung - drug effects; Lung - immunology; Lung - pathology; Mice, Inbred BALB C; Ovalbumin; Phytotherapy; Reactive Oxygen Species - metabolism; Spleen - cytology; Spleen - immunology; STAT6 Transcription Factor - immunology; Th2 Cells - immunology; 18β IL-5; glycyrrhetinic acid; asthma; IL-13; Foxp3; GATA-3; 18β-glycyrrhetinic acid; Asthma
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2017.03.011

Graphical abstract Proposed mechanisms of 18Gly in a mouse model of allergic asthma.