Sleep-disordered breathing in severe mental illness: clinical evaluation of oximetry diagnosis and management limitations

• Published in: Sleep & breathing Vol. 25; no. 3; pp. 1433 - 1440
• Main Authors: Espinel, P., Marshall, N., Yee, B. J., Hollis, J., Smith, K., D’Rozario, A. L., Gauthier, G., Lambert, T., Grunstein, R. R.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2021; Springer Nature B.V
• Subjects: Adolescent; Adult; Apnea; Dentistry; Diagnosis; Feasibility Studies; Female; Humans; Hypoventilation; Internal Medicine; Male; Mass Screening - methods; Medicine; Medicine & Public Health; Mental disorders; Mental Disorders - epidemiology; Middle Aged; Neurology; Otorhinolaryngology; Oximetry; Patient Acceptance of Health Care - statistics & numerical data; Patient Acuity; Patients; Pediatrics; Pneumology/Respiratory System; Population studies; Psychosis; Retrospective Studies; Sleep; Sleep apnea; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - therapy; Sleep Breathing Physiology and Disorders • Original Article; Sleep disorders; Young Adult; Severe mental illness; Clinical audit; Schizophrenia; Obstructive sleep apnea; Oximetry; Sleep-disordered breathing
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-020-02259-y

Background To describe the diagnosis and management pathway of sleep-disordered breathing (SDB) in a sample of patients with severe mental illness (SMI), and to assess the feasibility and patient acceptability of overnight oximetry as a first-step screening method for detecting severe SDB in this population. Methods The study was a retrospective audit of patients with SMI seen at a Collaborative Centre for Cardiometabolic Health in Psychosis service who were invited for overnight oximetry between November 2015 and May 2018. The adjusted oxygen desaturation index (ODI) was calculated using 4% desaturation criteria. Results were discussed with a sleep specialist and categorized into a 4-level risk probability tool for SDB. Results Of 91 adults consenting for overnight oximetry, 90 collected some oximetry data, though 11 of these 90 patients collected technically unsatisfactory oximetry. Thus 79/90 patients (88%) collected adequate oximetry data for at least one night. The oximetry traces suggested likely minimal obstructive sleep apnea (OSA) in 41 cases, moderate to severe OSA in 25 patients, severe OSA in 9 patients and possible obesity hypoventilation syndrome (OHS) in 4 cases. Full polysomnography was recommended for 39 patients but only one-third underwent testing. Nineteen patients were reviewed by a sleep specialist. Of the 10 patients who initiated CPAP, four were considered adherent to treatment. Conclusion Home oximetry may be a pragmatic option for SDB screening in patients with SMI but reliable full diagnostic and management pathways need to be developed.