Single-cell multiomic analyses sheds light on mitochondrial mutational selection

Single large-scale mitochondrial DNA deletions cause a spectrum of disease with differing severities and tissue expressivity. Quantification of single-cell deletion levels with multi-modal cellular readouts provides insights into hematopoietic cell fate and disease manifestation.

Saved in:
Bibliographic Details
Published inNature genetics Vol. 55; no. 7; pp. 1083 - 1085
Main Authors Pickett, Sarah J., Hudson, Gavin, Greaves, Laura C.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.07.2023
Nature Publishing Group
Subjects
38/39
631/337/2019
631/337/475
82/1
82/80
Agriculture
Anemia
Animal Genetics and Genomics
Apoptosis
Biomedical and Life Sciences
Biomedicine
Biosynthesis
Blood
Bone marrow
Cancer Research
CD8 antigen
Cell culture
Clonal deletion
Diabetes
Disease
Effector cells
Erythrocytes
Gene deletion
Gene expression
Gene Function
Hematology
Heteroplasmy
Human Genetics
Informatics
Lymphocytes
Lymphocytes T
Medical research
Memory cells
Metabolism
Mitochondria
Mitochondrial DNA
News & Views
news-and-views
Organelles
Oxidative phosphorylation
Phosphorylation
Sulfur
United Kingdom > UK
Online AccessGet full text

Cover

More Information
Summary:Single large-scale mitochondrial DNA deletions cause a spectrum of disease with differing severities and tissue expressivity. Quantification of single-cell deletion levels with multi-modal cellular readouts provides insights into hematopoietic cell fate and disease manifestation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-023-01436-5