Thyroiditis and COVID-19: focus on pediatric age. A narrative review

• Published in: Journal of endocrinological investigation Vol. 47; no. 7; pp. 1633 - 1640
• Main Authors: d’Aniello, F., Amodeo, M. E., Grossi, A., Ubertini, G.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2024; Springer Nature B.V
• Subjects: ACE2; Adolescent; Angiotensin; Angiotensin-converting enzyme 2; Autoimmune diseases; Child; COVID-19; COVID-19 - complications; COVID-19 - epidemiology; Endocrinology; Graves Disease - complications; Graves Disease - epidemiology; Hashimoto Disease - epidemiology; Humans; Incidence; Infections; Inflammation; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Multisystem inflammatory syndrome in children; Pediatrics; Peptidyl-dipeptidase A; Risk factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Short Review; Systemic Inflammatory Response Syndrome - epidemiology; Thyroid diseases; Thyroiditis; Thyroiditis - epidemiology; Thyroiditis; COVID-19; SARS-CoV2; Pediatric age; Autoimmune diseases; Thyroid diseases
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-024-02331-4

Purpose In light of the growing concern over the possible link between SARS-CoV2 infection and autoimmune diseases, we conducted a review to investigate the impact of the pandemic outbreak on thyroid diseases. Methods We carried out a narrative review of all pediatric cases described in the literature, mainly focusing on the possible association of COVID-19 with the incidence of autoimmune and post-infective thyroid diseases (namely Hashimoto’s Thyroiditis (HT), Grave’s Disease (GD) and Sub-Acute Thyroiditis (SAT)). We also felt it was necessary to provide a brief review of Non-thyroidal Illness Syndrome (NTIS) and Multisystem Inflammatory Syndrome in Children (MIS-C) because of their overlap with thyroiditis. Results There is currently no conclusive evidence linking SARS-CoV-2 infection with an increased incidence of autoimmune thyroiditis (AT) in pediatric age. However, SAT may be a mild complication of SARS-CoV-2 infection, as is the case with other viral infections. SAT typically resolves on its own and does not require treatment. NTIS may be associated with inflammatory complications, such as MIS-C, and admission to intensive care. It may also be considered a prognostic risk factor for severe disease. The hypothesized pathogenetic mechanisms of thyroid damage in COVID-19 include direct damage due to the significant expression of angiotensin-converting enzyme 2 (ACE2) in the thyroid gland, which is a ligand for the virus, and indirect damage due to immune dysregulation, such as the overproduction of IL-6, which is thought to be part of the pathogenesis of thyroiditis. Conclusion However, due to the limited evidence available, further prospective longitudinal studies are required to clarify the relationship between COVID-19 and thyroid disease in children and adolescents, as well as to investigate any potential long-term consequences.