SLCO1B1 Polymorphisms are Associated with the Susceptibility to Pulmonary Tuberculosis in Chinese Females

• Published in: Biochemical genetics Vol. 62; no. 1; pp. 385 - 394
• Main Authors: Li, Wei, Liu, Wei, Wang, Xiong, Dou, Rui, Zhu, Zunmin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2024; Springer Nature B.V
• Subjects: Age; Biochemistry; Biomedical and Life Sciences; Biomedicine; Chi-square test; Confidence intervals; Females; Genotyping; Haplotypes; Human Genetics; Medical Microbiology; Original Article; Regression analysis; Risk; Statistical analysis; Tuberculosis; Zoology; SLCO1B1; Tuberculosis; Susceptibility; Chinese females; Polymorphism
• ISSN: 0006-2928; 1573-4927
• DOI: 10.1007/s10528-023-10392-y

This study aimed to evaluate the role of SLCO1B1 polymorphisms in pulmonary tuberculosis (PTB) risk among Chinese patients. This study comprised 600 PTB patients (mean age: 37.43 ± 12.73 years) and 600 healthy controls (mean age: 37.39 ± 12.57 years) from a Chinese population. The SLCO1B1 rs2306283 and rs4149056 polymorphisms were detected using TaqMan genotyping assay. Chi-square (χ 2 ) test was applied to calculate the Hardy–Weinberg Equilibrium (HWE) among controls. Logistic regression analysis was used to examine the odds ratio (OR) and 95% confidence interval (CI). After adjustment for age and gender, the frequency of rs4149056-C was significantly higher in PTB group ( P  = 0.017, OR = 1.375, 95% CI 1.058–1.786); meanwhile, rs4149056 was associated with increased PTB risk in dominant model ( P  = 0.015, OR = 1.424, 95% CI 1.072–1.892). The frequency and genotype of rs2306283 showed no significant difference between the two groups. In stratified analysis, rs2306283-GG showed notable susceptibility to PTB ( P  = 0.027, OR = 1.563, 95% CI 1.051–2.323 in recessive model) in females; rs4149056-C was also significantly higher in female PTB group ( P  = 0.039, OR = 1.741, 95% CI 1.028–2.948). Neither of rs2306283 and rs4149056 polymorphisms was associated with PTB risk in males. A haplotype analysis showed that patients carrying at least one SLCO1B1 *15 haplotype had higher PTB risk ( P  = 0.004, OR = 1.527, 95% CI 1.145–2.034). SLCO1B1 polymorphisms are associated with the susceptibility to pulmonary tuberculosis in Chinese females.