Neuroblastoma presenting with the nephrotic syndrome

• Published in: Journal of pediatric surgery Vol. 14; no. 4; pp. 414 - 419
• Main Authors: Zheng, Han-Long, Maruyama, Tsuyoshi, Matsuda, Shin, Satomura, Kisaku
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.1979
• Subjects: Child, Preschool; Humans; Male; nephrotic syndrome; Nephrotic Syndrome - diagnostic imaging; Nephrotic Syndrome - etiology; Nephrotic Syndrome - pathology; Neuroblastoma; Neuroblastoma - complications; Neuroblastoma - diagnostic imaging; Neuroblastoma - pathology; Radiography; Retroperitoneal Neoplasms - complications; Retroperitoneal Neoplasms - diagnostic imaging; Retroperitoneal Neoplasms - pathology; nephrotic syndrome; Neuroblastoma
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1016/S0022-3468(79)80003-2

A case of neuroblastoma in a 4-yr-old boy presenting with the nephrotic syndrome is reported. Neither thrombosis nor stenosis of the renal veins and the inferior vena cava was present. Electron microscopy revealed lumps of subepithelial deposits as well as thickening and tortuosity of the glomerular basement membrane compatible with membranous nephropathy. It is postulated that deposition of neuroblastoma-associated immune complexes on the glomerular basement membrane-was responsible for the development of the nephrotic syndrome in this patient. Five pediatric cases of nephrotic syndrome associated with extrarenal neoplasia were collected from the world literature and are briefly discussed.