Advanced considerations in survival analysis

Abstract Investigation of survival during the follow-up period is common in cardiovascular research and has intrinsic issues that require precise knowledge, such as survival or censoring. Besides, as the follow-up period lengthens and events other than mortality are studied, the analysis becomes mor...

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Published inEuropean journal of cardio-thoracic surgery Vol. 65; no. 2
Main Authors Carnero-Alcázar, Manuel, Montero-Cruces, Lourdes, Cobiella-Carnicer, Javier, Pérez-Camargo, Daniel, Maroto Castellanos, Luis
Format Journal Article
LanguageEnglish
Published Germany Oxford University Press 01.02.2024
Subjects
proportional hazards assumption
competing risks analysis
survival analysis
restricted mean survival time
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Summary:Abstract Investigation of survival during the follow-up period is common in cardiovascular research and has intrinsic issues that require precise knowledge, such as survival or censoring. Besides, as the follow-up period lengthens and events other than mortality are studied, the analysis becomes more complex, so Kaplan–Meier analyses or Cox models are not always sufficient. In this primer, we provide the reader with detailed information on the interpretation of the most common survival analyses and delve into methods to analyse competing risks or alternatives to the conventional methods when the proportional hazards assumption is not met. Some basic aspects of survival analysis in cardiothoracic research were discussed previously in a primer published in Interdisciplinary Cardiovascular and Thoracic Surgery [1].
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ISSN:1873-734X
1873-734X
DOI:10.1093/ejcts/ezae020