Effectiveness of endovascular treatment for in-hospital stroke vs. community-onset stroke: a propensity score-matched analysis

• Published in: Journal of neurology Vol. 271; no. 5; pp. 2684 - 2693
• Main Authors: Jung, Jae Wook, Kim, Kwang Hyun, Yun, Jaeseob, Nam, Hyo Suk, Heo, Ji Hoe, Baik, Minyoul, Yoo, Joonsang, Kim, Jinkwon, Park, Hyungjong, Sohn, Sung-Il, Hong, Jeong-Ho, Kim, Byung Moon, Kim, Dong Joon, Heo, JoonNyung, Bang, Oh Young, Seo, Woo-Keun, Chung, Jong-Won, Lee, Kyung-Yul, Jung, Yo Han, Lee, Hye Sun, Ahn, Seong Hwan, Shin, Dong Hoon, Choi, Hye-Yeon, Cho, Han-Jin, Baek, Jang-Hyun, Kim, Gyu Sik, Seo, Kwon-Duk, Kim, Seo Hyun, Song, Tae-Jin, Han, Sang Won, Park, Joong Hyun, Choi, Jin Kyo, Kim, Young Dae
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2024; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Cardiovascular system; Cohort Studies; Endovascular Procedures; Female; Hospitalization - statistics & numerical data; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neuroradiology; Neurosciences; Original Communication; Outcome Assessment, Health Care; Patients; Propensity Score; Prospective Studies; Registries; Safety; Stroke; Stroke - therapy; Thrombectomy - methods; Thrombolysis; Thrombolytic Therapy; Treatment Outcome; Propensity score; Ischemic stroke; Endovascular treatment; In-hospital stroke
• ISSN: 0340-5354; 1432-1459; 1432-1459
• DOI: 10.1007/s00415-024-12232-4

Background The effectiveness of endovascular treatment for in-hospital stroke remains debatable. We aimed to compare the outcomes between patients with in-hospital stroke and community-onset stroke who received endovascular treatment. Methods This prospective registry-based cohort study included consecutive patients who underwent endovascular treatment from January 2013 to December 2022 and were registered in the Selection Criteria in Endovascular Thrombectomy and Thrombolytic Therapy study and Yonsei Stroke Cohort. Functional outcomes at day 90, radiological outcomes, and safety outcomes were compared between the in-hospital and community-onset groups using logistic regression and propensity score-matched analysis. Results Of 1,219 patients who underwent endovascular treatment, 117 (9.6%) had in-hospital stroke. Patients with in-hospital onset were more likely to have a pre-stroke disability and active cancer than those with community-onset. The interval from the last known well to puncture was shorter in the in-hospital group than in the community-onset group (155 vs. 355 min, p <0.001). No significant differences in successful recanalization or safety outcomes were observed between the groups; however, the in-hospital group exhibited worse functional outcomes and higher mortality at day 90 than the community-onset group (all p <0.05). After propensity score matching including baseline characteristics, functional outcomes after endovascular treatment did not differ between the groups (OR: 1.19, 95% CI 0.78–1.83, p =0.4). Safety outcomes did not significantly differ between the groups. Conclusion Endovascular treatment is a safe and effective treatment for eligible patients with in-hospital stroke. Our results will help physicians in making decisions when planning treatment and counseling caregivers or patients.