Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation

• Published in: International journal of hematology Vol. 119; no. 5; pp. 583 - 591
• Main Authors: Kuroiwa, Kai, Sato, Misuzu, Narita, Hinako, Okamura, Reiko, Uesugi, Yuka, Sasaki, Yohei, Shimada, Shotaro, Watanuki, Megumi, Fujiwara, Shun, Kawaguchi, Yukiko, Arai, Nana, Yanagisawa, Kouji, Iezumi, Keiichi, Hattori, Norimichi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.05.2024; Springer Nature B.V
• Subjects: Adolescent; Adult; Allografts; Antigens; Bone marrow; Clinical outcomes; Comorbidity; Female; Forkhead Transcription Factors - genetics; Foxp3 protein; Gene polymorphism; Genetic testing; Genotype; Genotype & phenotype; Graft versus host disease; Graft vs Host Disease - etiology; Graft vs Host Disease - genetics; Graft-versus-host reaction; Hematologic Neoplasms - genetics; Hematologic Neoplasms - therapy; Hematology; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Humans; Leukemia; Leukocytes; Lymphocytes; Lymphoma; Male; Malignancy; Medicine; Medicine & Public Health; Middle Aged; Multivariate analysis; Myelodysplastic syndromes; Nucleotides; Oncology; Original Article; Patients; Polymorphism; Polymorphism, Single Nucleotide; Single-nucleotide polymorphism; Stem cell transplantation; Stem cells; Systems analysis; Transplantation; Transplantation, Homologous; Umbilical cord; Young Adult; Graft-versus-host disease; Allogeneic hematopoietic stem cell transplantation; Polymorphism; FOXP3
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-024-03726-y

The impact of FOXP3 single-nucleotide polymorphisms (SNP) on clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly understood. We investigated the relationship between a FOXP3 SNP (rs3761548) and clinical outcomes in 91 patients with hematological malignancies after allo-HSCT. Multivariate analysis showed that risk of severe chronic graft-versus-host disease (cGVHD) was significantly higher in patients with the FOXP3 -3279C/A or FOXP3 -3279A/A genotype than those with the FOXP3 -3279C/C genotype [hazard ratio (HR), 2.69; 95% confidence interval (CI) 1.14–6.31; p  = 0.023]. Therefore, FOXP3 at SNP rs3761548 can be a useful marker for predicting the occurrence of severe cGVHD.