Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy
Anti-DNER antibody is associated with paraneoplastic cerebellar degeneration (PCD) and Hodgkin’s disease (HD). However, recent studies reported cases absence of HD and that non-tumor anti-DNER antibody-associated ataxia was not well characterized. We present a case of acute cerebellar ataxia and nys...
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Published in | Cerebellum (London, England) Vol. 23; no. 4; pp. 1697 - 1701 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.08.2024
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Anti-DNER antibody is associated with paraneoplastic cerebellar degeneration (PCD) and Hodgkin’s disease (HD). However, recent studies reported cases absence of HD and that non-tumor anti-DNER antibody-associated ataxia was not well characterized. We present a case of acute cerebellar ataxia and nystagmus with detected anti-DNER antibody. Brain magnetic resonance imaging (MRI) showed cerebellar atrophy. High titer of anti-DNER antibody was detected in CSF and serum. Positron emission tomography (PET) scanning was unremarkable at a 10-month follow up. The patient improved significantly after immunosuppressive therapy with intravenous steroids, immunoglobulin followed by rituximab. Our study suggest that the presence of such anti-neuronal antibodies might not come along with malignancy and that early onset non-tumor patients are more likely to have a better outcome after immunotherapy. Early diagnosis and timely immunosuppressive therapy may prove beneficial for these patients. |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 1473-4230 1473-4222 1473-4230 |
DOI: | 10.1007/s12311-023-01636-z |