The use of botulinum toxin in the acute management of symptomatic complex incisional hernia: a case series

• Published in: Hernia : the journal of hernias and abdominal wall surgery Vol. 27; no. 3; pp. 593 - 599
• Main Authors: Stevens, J., Baillie, C., Choi, B., Chapman, A., Kostalas, M., Ratnasingham, K.
• Format: Journal Article
• Language: English
• Published: Paris Springer Paris 01.06.2023; Springer Nature B.V
• Subjects: Abdomen; Abdominal Surgery; Abdominal wall; Abdominal Wall - surgery; Aged; Botulinum toxin; Botulinum toxin type A; Botulinum Toxins, Type A - therapeutic use; Hernia; Hernia, Ventral - drug therapy; Hernia, Ventral - surgery; Hernias; Herniorrhaphy - adverse effects; Herniorrhaphy - methods; Humans; Incisional Hernia - surgery; Ischemia; Medicine; Medicine & Public Health; Original Article; Risk groups; Surgery; Surgical Mesh; Complex abdominal wall hernia; Botox; Incisional hernia
• ISSN: 1248-9204; 1265-4906; 1248-9204
• DOI: 10.1007/s10029-023-02739-6

Purpose Complications of incisional hernia are amongst the commonest presentations to the emergency surgical take. Outcomes from emergency hernia repair are poor, particularly for those with complex defects and for the growing population of comorbid, high-risk patients. Attempts to avoid emergency surgery by improving success rates of non-operative management could prove hugely beneficial. Botulinum toxin A (Botox) is already used in the elective management of incisional hernia and this study evaluates if the relaxation produced could be used to augment the outcomes of conservative management of acutely presenting incisional hernia. Methods Patients presenting between October 2020 and April 2022 without evidence of visceral ischaemia, who had been selected for a non-operative approach, were given 300 units of Botox under image guidance to the abdominal wall in addition to standard conservative measures. Results Twelve patients were eligible for Botox administration. Median age was 75 years and median BMI was 36.45 kg/m 2 . All patients were high risk; minimum ASA score was 3, and median frailty score was 5. In ten patients, symptoms resolved following Botox allowing for discharge without further complication. Seven subsequently referred on to the abdominal wall team. Symptoms did not settle in the two remaining patients; one required emergency laparotomy and the second was palliated. Conclusion Botox may be a useful adjunct to established non-operative measures in patients with acute presentations of incisional hernia. It may improve the acute symptoms, eliminate the need for high-risk emergency surgery, or provide a bridge to abdominal wall reconstruction.