Screening value of lung ultrasound and pleural shear wave elastography in connective tissue disease–related interstitial lung disease: a preliminary study

• Published in: Clinical rheumatology Vol. 43; no. 6; pp. 2117 - 2123
• Main Authors: Han, Shiyao, Ji, Ziyao, Liu, Yanjun
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2024; Springer Nature B.V
• Subjects: Adult; Aged; Computed tomography; Connective tissue diseases; Connective Tissue Diseases - complications; Connective Tissue Diseases - diagnostic imaging; Correlation analysis; Elasticity Imaging Techniques - methods; Female; Humans; Lung - diagnostic imaging; Lung - physiopathology; Lung diseases; Lung Diseases, Interstitial - complications; Lung Diseases, Interstitial - diagnostic imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Pleura - diagnostic imaging; Rheumatology; ROC Curve; Sensitivity and Specificity; Statistical analysis; Tomography, X-Ray Computed; Ultrasonic imaging; Ultrasonography - methods; Ultrasound; Connective tissue disease; Pleural shear wave elastography; Lung ultrasound; B-lines; Interstitial lung disease; High-resolution computed tomography
• ISSN: 0770-3198; 1434-9949; 1434-9949
• DOI: 10.1007/s10067-024-06983-8

Objective To explore the diagnostic value of lung ultrasound (LUS) and pleural shear wave elastography (SWE) for connective tissue disease–interstitial lung disease (CTD-ILD). Methods We selected 104 patients diagnosed with connective tissue disease (CTD) at our hospital. All patients underwent LUS, SWE, and high-resolution computed tomography (HRCT). With HRCT as the imaging gold standard for diagnosis, patients were categorized into CTD-ILD and CTD-non-ILD groups. We employed paired chi-square tests to compare the diagnostic differences between HRCT and LUS for ILD. Receiver operating characteristic (ROC) curves were used to assess the diagnostic value of pleural SWE for ILD. Correlation analysis was performed between pleural elasticity values and lung ultrasound scores. Results The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of LUS for diagnosing CTD-ILD were 93.3%, 86.2%, 6.761, and 0.078, respectively. There was no statistically significant difference in the results between HRCT and LUS ( P  = 1.000), with a kappa value of 0.720 ( P  < 0.001). There was a statistically significant difference in the pleural elasticity in the bilateral lower back region between the case and control groups ( P  < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for pleural SWE in diagnosing CTD-ILD was 0.685. In CTD-ILD patients, there was no significant correlation between pleural elasticity values and LUS scores ( P  > 0.05). Conclusion The LUS can serve as an important imaging method for screening for CTD-ILD and assessing the severity of the disease. However, pleural SWE has been shown to demonstrate lower diagnostic efficacy for CTD-ILD, and its ability to assess disease severity is limited. Key Points • The LUS can serve as an important imaging method for screening for CTD-ILD and assessing the severity of the disease. • Pleural SWE has been shown to demonstrate lower diagnostic efficacy for CTD-ILD, and its ability to assess disease severity is limited.