Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

A structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives. Graphic

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 3; no. 4; pp. 375 - 381
Main Authors Groutas, William C., Brubaker, Michael J., Chong, Lee S., Venkataraman, Radhika, Huang, He, Epp, Jeffrey B., Kuang, Rongze, Hoidal, John R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1995
Subjects
Amino Acids - chemistry
Cathepsin G
Cathepsins - antagonists & inhibitors
Drug Design
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
Leukocyte Elastase
Myeloblastin
Pancreatic Elastase - antagonists & inhibitors
Serine Endopeptidases - drug effects
Serine Proteinase Inhibitors - pharmacology
Structure-Activity Relationship
Succinimides - chemical synthesis
Succinimides - chemistry
Succinimides - pharmacology
Time Factors
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Summary:A structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives. Graphic
ISSN:0968-0896
1464-3391
DOI:10.1016/0968-0896(95)00024-B