Risk of metastasis and survival in patients undergoing different treatment strategies with T1 colonic neuroendocrine tumors

• Published in: Journal of endocrinological investigation Vol. 47; no. 3; pp. 671 - 681
• Main Authors: Wu, X., Peng, C., Lin, M., Li, Z., Yang, X., Liu, J., Zuo, X.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2024; Springer Nature B.V
• Subjects: Colon; Databases, Factual; Endocrinology; Epidemiology; Humans; Internal Medicine; Medical prognosis; Medicine; Medicine & Public Health; Metabolic Diseases; Metastases; Metastasis; Neuroendocrine tumors; Neuroendocrine Tumors - surgery; Original Article; Patients; Prognosis; Risk Factors; Survival; SEER; Treatment strategies; Colonic neuroendocrine tumors; Survival; Metastasis risk
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-023-02185-2

Purpose The efficacy and safety of local excision (LE) for small (< 1‒2 cm) colonic neuroendocrine tumors (NETs) is controversial due to the higher metastasis risk when compared with rectal NETs. The study aimed to evaluate the metastasis risk of T1 colonic NETs and compare patients' long-term prognosis after LE or radical surgery (RS). Methods The Surveillance Epidemiology and End Results database was used to identify patients with T1 colonic NETs (2004‒2015). Multivariable logistic regression was performed to assess factors associated with metastasis risk. Propensity score matching was used to balance the variables. Cancer-specific survival (CSS) and overall survival (OS) were calculated to estimate the prognosis of patients with T1N0M0 colonic NETs who underwent LE or RS. Results Of the 610 patients with colonic NETs, 46 (7.54%) had metastasis at diagnosis. Tumor size (11–20 mm) (OR = 9.51; 95% confidence interval (CI): 4.32‒21.45; P < 0.001), right colon (OR = 15.79; 95% CI 7.20‒38.56; P < 0.001), submucosal infiltration (OR = 2.08; 95% CI 0.84‒5.57; P = 0.125) were independent risk factors associated with metastasis. Of the 515 patients with T1N0M0 colonic NETs, the overall long-term prognosis of LE was as good as that of RS groups (after matching, 5-year CSS: 97.9% vs. 94.6%, P = 0.450; 5-year OS: 92.7% vs. 85.6%, P = 0.009). Conclusion Tumor size (11‒20 mm) and site (right colon) are associated with metastasis in T1 colonic NETs. In the absence of metastasis, LE could be a viable option for 0‒10 mm T1 colonic NETs with well/moderate differentiation in the left colon in terms of long-term survival.