A water-soluble near-infrared fluorescent probe for specific Pd2+ detection

• Published in: Bioorganic & medicinal chemistry Vol. 26; no. 4; pp. 931 - 937
• Main Authors: Wen, Jia, Lv, Yinghua, Xia, Pengyi, Liu, Fengyu, Xu, Yongqian, Li, Hongjuan, Chen, Su-Shing, Sun, Shiguo
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.02.2018; Elsevier
• Subjects: Biochemistry & Molecular Biology; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Imaging; Life Sciences & Biomedicine; Naphthofluorescein; Near-infrared fluorescence; Pd2+ detection; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; Water solubility; Water solubility; Naphthofluorescein; Pd2+ detection; Imaging; Near-infrared fluorescence; OPTICAL-DETECTION; TURN-ON CHEMODOSIMETER; PALLADIUM IONS; CATALYZED REACTIONS; IMAGING PALLADIUM; AQUEOUS-SOLUTION; PURE WATER; PD MEDIATED REACTION; SELECTIVE DETECTION; LIVING CELLS
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2017.12.003

A novel near-infrared fluorescent probe M-PD has been developed for selective detection of Pd2+ based on naphthofluorescein. [Display omitted] Palladium (Pd) is widely used in chemistry, biology, environmental science etc., and Pd2+ is the most plenitudinous oxidation state of the Pd that can exist under physiological conditions or in living cells, which could have adverse effects on both our health and environment. Thus, it is of great significance to monitor the changes of Pd2+. Hence, a novel near-infrared fluorescent probe M-PD has been developed for selective detection of Pd2+ based on naphthofluorescein in this work. The result demonstrated that M-PD exhibited favorable properties for sensing Pd2+ such as excellent water solubility, high selectivity and sensitivity. And the limit of detection was estimated as 10.8 nM, much lower than the threshold in drugs (5–10 ppm) specified by European Directorate for the Quality Control of Medicines. More importantly, detection and recovery experiments of Pd2+ in aspirin aqoeous solution and soil are satisfactory. In addition, M-PD has also been successfully used for near-infrared fluorescence imaging of Pd2+ in living cells, indicating that the probe has better feasibility and application potential in the determination of Pd2+.