Comparison of gut microbiota profiles between patients suffering from elderly frailty syndrome and non-frail elderly individuals

Background Frailty syndrome is a state of increased vulnerability to stressors, marked by lowered physical strength and increased dependence on others. The well-established changes in gut microbiota associated with old age suggest a probable relationship between gut microbiota and frailty. Methods a...

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Published inMolecular biology reports Vol. 51; no. 1; p. 321
Main Authors Mirfakhraee, Hosna, Sabaei, Milad, Niksolat, Maryam, Faraji, Fatemeh, Saghafian Larijani, Samaneh, Rahmani Fard, Soheil, Zandieh, Zhale, Minaeian, Sara
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.12.2024
Springer Nature B.V
Subjects
Aged
Animal Anatomy
Animal Biochemistry
Bacteria
Bacteroidetes
Biomedical and Life Sciences
Frail Elderly
Frailty
Gastrointestinal Microbiome - genetics
Histology
Humans
Intestinal microflora
Life Sciences
Microbiota
Morphology
Original Article
Prevotella
Gut microbiota
Microbiota
qPCR
Elderly
Frailty syndrome
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Summary:Background Frailty syndrome is a state of increased vulnerability to stressors, marked by lowered physical strength and increased dependence on others. The well-established changes in gut microbiota associated with old age suggest a probable relationship between gut microbiota and frailty. Methods and results This study was aimed at finding the relationship between gut microbiota and frailty syndrome, by comparing the sociodemographic data and the gut microbiota profiles of 23 non-frail and 14 frail elderly individuals. We used the quantitative polymerase chain reaction method (qPCR) to determine the bacterial loads of Bifidobacteria, Lactobacillus , Bacteroidetes, Prevotella , and Escherichia coli in stool samples from test subjects. We discovered a significant increase in the bacterial load of Prevotella in frail elderly individuals aged 70 or above. Other bacterial loads and ratios were not significantly different between the two groups. Conclusions More comprehensive studies with larger sample sizes and encompassing a wider range of inflammation-related bacteria need to be performed to discover the existence and exact nature of these relations.
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ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-024-09271-5