The Prolonged Masking of Temporal Acoustic Inputs with Noise Drives Plasticity in the Adult Rat Auditory Cortex

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 29; no. 3; pp. 1032 - 1046
• Main Authors: Thomas, Maryse E, Friedman, Nathan H M, Cisneros-Franco, J Miguel, Ouellet, Lydia, de Villers-Sidani, Étienne
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2019
• Subjects: Acoustic Stimulation; Animals; Auditory Cortex - physiology; Auditory Perception - physiology; Critical Period, Psychological; Female; Neuronal Plasticity; Noise; Perceptual Masking - physiology; Rats, Long-Evans; Time Factors; experience-dependent plasticity; auditory cortex; noise exposure; parvalbumin; somatostatin
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhy009

Abstract The prolonged masking of auditory inputs with white noise has been shown to reopen the critical period for spectral tuning in the adult rat auditory cortex. Here, we argue that the masking of salient temporal inputs in particular is responsible for changes in neuronal activity that lead to this experience-dependent plasticity. We tested this hypothesis by passively exposing adult rats to 2 weeks of amplitude-modulated (AM) white noise with different modulation depths from 0% (no modulation) to 100% (strong modulation). All exposed rats displayed evidence of cortical plasticity as measured by receptive field bandwidths, tonotopic gradients, and synchronization during spontaneous activity. However, this plasticity was fundamentally different in nature for rats exposed to unmodulated noise, as a second passive exposure to pure tones elicited tonotopic reorganization in rats exposed to 0% AM noise only. Detection of c-FOS expression in excitatory and inhibitory cells through post-mortem immunohistochemistry also revealed different patterns of cellular activation depending on modulation depth. Together, these results indicate that the absence of temporal modulation promotes noise-induced plasticity in the adult auditory cortex and suggest an important and continuous role for temporally salient inputs in the maintenance of mature auditory circuits.