Polymorphisms in nanog are associated with oral leukoplakia: case–control study
To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case–control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG , through real-time polymerase chain r...
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| Published in | Odontology Vol. 113; no. 3; pp. 1263 - 1268 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Springer Nature Singapore
01.07.2025
Springer Nature B.V |
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| Abstract | To investigate the association of
NANOG
polymorphisms with oral leukoplakia. In this case–control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in
NANOG
, through real-time polymerase chain reaction (PCR). Pearson’s chi-squared and Fisher’s exact statistical tests were used, with a significance of 5%. For the dominant genetic model of the G allele of rs877716, the genotypes AG + GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75,4 and 50% respectively; p = 0,031). Subjects with this genotype were 3,063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7, 5% respectively; p = 0, 01). There was no association found in the other genetic models. Polymorphisms in
NANOG
are associated with oral leukoplakia. |
|---|---|
| AbstractList | To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case–control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson’s chi-squared and Fisher’s exact statistical tests were used, with a significance of 5%. For the dominant genetic model of the G allele of rs877716, the genotypes AG + GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75,4 and 50% respectively; p = 0,031). Subjects with this genotype were 3,063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7, 5% respectively; p = 0, 01). There was no association found in the other genetic models. Polymorphisms in NANOG are associated with oral leukoplakia. To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson's chi-squared and Fisher's exact statistical tests were used, with a significance of 5%. For the dominant genetic model of the G allele of rs877716, the genotypes AG + GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75,4 and 50% respectively; p = 0,031). Subjects with this genotype were 3,063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7, 5% respectively; p = 0, 01). There was no association found in the other genetic models. Polymorphisms in NANOG are associated with oral leukoplakia.To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson's chi-squared and Fisher's exact statistical tests were used, with a significance of 5%. For the dominant genetic model of the G allele of rs877716, the genotypes AG + GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75,4 and 50% respectively; p = 0,031). Subjects with this genotype were 3,063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7, 5% respectively; p = 0, 01). There was no association found in the other genetic models. Polymorphisms in NANOG are associated with oral leukoplakia. To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case–control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG , through real-time polymerase chain reaction (PCR). Pearson’s chi-squared and Fisher’s exact statistical tests were used, with a significance of 5%. For the dominant genetic model of the G allele of rs877716, the genotypes AG + GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75,4 and 50% respectively; p = 0,031). Subjects with this genotype were 3,063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7, 5% respectively; p = 0, 01). There was no association found in the other genetic models. Polymorphisms in NANOG are associated with oral leukoplakia. |
| Author | Johann, Aline Cristina Batista Rodrigues Scariot, Rafaela dos Santos, Emanuela Carla Jham, Bruno Correia Ignácio, Sergio Aparecido de Noronha, Lucia Aguiar, Maria Cassia Ferreira Tiboni, Fernanda de Souza, Cleber Machado Michels, Arieli Carini Scheifer, Suelen Teixeira Modolo, Filipe Marins, Mariana Hornung |
| Author_xml | – sequence: 1 givenname: Arieli Carini surname: Michels fullname: Michels, Arieli Carini organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 2 givenname: Suelen Teixeira surname: Scheifer fullname: Scheifer, Suelen Teixeira organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 3 givenname: Fernanda surname: Tiboni fullname: Tiboni, Fernanda organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 4 givenname: Filipe surname: Modolo fullname: Modolo, Filipe organization: Universidade Federal de Santa Catarina, Eng. Agronômico Andrei Cristian Ferreira – sequence: 5 givenname: Emanuela Carla surname: dos Santos fullname: dos Santos, Emanuela Carla organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 6 givenname: Rafaela surname: Scariot fullname: Scariot, Rafaela organization: Universidade Federal Do Paraná. Avenida Pref. Lothário Meissner – sequence: 7 givenname: Maria Cassia Ferreira surname: Aguiar fullname: Aguiar, Maria Cassia Ferreira organization: Universidade Federal de Minas Gerais. Avenida Presidente Antonio Carlos – sequence: 8 givenname: Sergio Aparecido surname: Ignácio fullname: Ignácio, Sergio Aparecido organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 9 givenname: Lucia surname: de Noronha fullname: de Noronha, Lucia organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 10 givenname: Mariana Hornung surname: Marins fullname: Marins, Mariana Hornung organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 11 givenname: Bruno Correia surname: Jham fullname: Jham, Bruno Correia organization: College of Dental Medicine - Illinois Midwestern University – sequence: 12 givenname: Cleber Machado surname: de Souza fullname: de Souza, Cleber Machado organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição – sequence: 13 givenname: Aline Cristina Batista Rodrigues orcidid: 0000-0002-1678-9363 surname: Johann fullname: Johann, Aline Cristina Batista Rodrigues email: aline.johann@pucpr.br organization: Pontifícia Universidade Católica Do Paraná. Imaculada Conceição |
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| Keywords | Nanog homeobox protein Embryonic stem cells Oral leukoplakia Genetic polymorphism |
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| Snippet | To investigate the association of
NANOG
polymorphisms with oral leukoplakia. In this case–control study, 68 cases of oral leukoplakia, and 21 of normal oral... To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral... To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case–control study, 68 cases of oral leukoplakia, and 21 of normal oral... |
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| SubjectTerms | Adult Alleles Case-Control Studies Dentistry Female Genetic Predisposition to Disease Genotype Genotyping Homeodomain Proteins - genetics Humans Leukokeratosis Leukoplakia, Oral - genetics Male Medicine Middle Aged Nanog Homeobox Protein - genetics Oral and Maxillofacial Surgery Original Article Polymerase chain reaction Polymorphism, Single Nucleotide Real-Time Polymerase Chain Reaction Statistical analysis |
| Title | Polymorphisms in nanog are associated with oral leukoplakia: case–control study |
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