Interface between Resolvins and Efferocytosis in Health and Disease

Acute inflammation resolution acts as a vital process for active host response, tissue support, and homeostasis maintenance, during which resolvin D (RvD) and E (RvE) as mediators derived from omega-3 polyunsaturated fatty acids display specific and stereoselective anti-inflammations like restrictin...

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Published inCell biochemistry and biophysics Vol. 82; no. 1; pp. 53 - 65
Main Authors Mohammad-Rafiei, Fatemeh, Negahdari, Samira, Tahershamsi, Zahra, Gheibihayat, Seyed Mohammad
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2024
Springer Nature B.V
Subjects
Anti-Inflammatory Agents
Apoptosis
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Cell Biology
Docosahexaenoic acid
Efferocytosis
Fatty Acids, Omega-3 - therapeutic use
Homeostasis
Humans
Inflammation
Leukocytes (neutrophilic)
Life Sciences
Macrophages
Pharmacology/Toxicology
Polyunsaturated fatty acids
Review Paper
Stereoselectivity
Efferocytosis
Aging
Liver diseases
Resolvin
Lung diseases
Cancer
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Summary:Acute inflammation resolution acts as a vital process for active host response, tissue support, and homeostasis maintenance, during which resolvin D (RvD) and E (RvE) as mediators derived from omega-3 polyunsaturated fatty acids display specific and stereoselective anti-inflammations like restricting neutrophil infiltration and pro-resolving activities. On the other side of the coin, potent macrophage-mediated apoptotic cell clearance, namely efferocytosis, is essential for successful inflammation resolution. Further studies mentioned a linkage between efferocytosis and resolvins. For instance, resolvin D1 (RvD1), which is endogenously formed from docosahexaenoic acid within the inflammation resolution, thereby provoking efferocytosis. There is still limited information regarding the mechanism of action of RvD1-related efferocytosis enhancement at the molecular level. The current review article was conducted to explore recent data on how the efferocytosis process and resolvins relate to each other during the inflammation resolution in illness and health. Understanding different aspects of this connection sheds light on new curative approaches for medical conditions caused by defective efferocytosis and disrupted inflammation resolution.
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ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-023-01187-4