Contractility drives the spatio-temporal coordination of morphogenesis and cell fate in hair follicles

Contractile activity of both the epithelium and underlying mesenchyme are required for epithelial deformation and cell fate acquisition during early mouse hair follicle development. Subsequently, localized basement membrane remodelling facilitates the release of tension-generated pressure to promote...

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Published inNature cell biology Vol. 26; no. 3; pp. 325 - 326
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2024
Nature Publishing Group
Subjects
631/136/532/2438
631/80
Basement membranes
Biology
Biomechanics
Biomedical and Life Sciences
Cancer
Cancer Research
Cell Biology
Cell cycle
Cell Differentiation
Cell fate
Contractility
Deformation
Developmental Biology
Epithelium
Extracellular matrix
Fibroblasts
Follicles
Hair
Hair Follicle
Life Sciences
Mesenchyme
Morphogenesis
Morphology
Research Briefing
Stem Cells
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Summary:Contractile activity of both the epithelium and underlying mesenchyme are required for epithelial deformation and cell fate acquisition during early mouse hair follicle development. Subsequently, localized basement membrane remodelling facilitates the release of tension-generated pressure to promote cell divisions, tissue fluidification and downgrowth of the developing hair follicle.
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ISSN:1465-7392
1476-4679
1476-4679
DOI:10.1038/s41556-024-01371-5