Anaesthesia-induced hyperglycaemia early in life is not predictive for development of diabetes in diabetes-prone BB rats

Type 1 diabetes (T1D) is an autoimmune disease in genetically predisposed individuals characterised by selective destruction of the beta-cells. Development of diabetes is in the asymptomatic pre-diabetic period characterised by impaired first-phase insulin response and the first clinical symptom is...

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Published inActa diabetologica Vol. 42; no. 2; pp. 95 - 98
Main Authors Sparre, T, Ejrnaes Sprinkel, A M, Bjerre Christensen, U, Karlsen, A E, Pociot, F, Nerup, J
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.06.2005
Subjects
Anesthesia
Anesthesia - adverse effects
Animals
Blood Glucose - metabolism
Comparative analysis
Diabetes
Diabetes Mellitus, Type 1 - physiopathology
Health risk assessment
Hyperglycemia - epidemiology
Hyperglycemia - etiology
Medical disorders
Prediabetic State
Prevalence
Rats
Rats, Inbred BB
Regression analysis
Rodents
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Summary:Type 1 diabetes (T1D) is an autoimmune disease in genetically predisposed individuals characterised by selective destruction of the beta-cells. Development of diabetes is in the asymptomatic pre-diabetic period characterised by impaired first-phase insulin response and the first clinical symptom is elevated blood glucose (BG). It is still uncertain whether stress or incidental hyperglycaemia can be regarded as predictors for development of T1D or not, even when immunologic and genetic markers for T1D are considered. The aim of this study was to investigate if there was any relationship between elevated BG in 30-day-old anaesthetised pre-diabetic diabetes-prone Bio Breeding (BB-DP) rats and later development of diabetes. Rats anaesthetised by intraperitoneal (ip) injection for islet transplantation displayed significantly higher BG values (Delta1.27 mmol/l, p=8.27x10(-12)) compared to non-anaesthetised non-transplanted rats, indicating that ip injection and/or anaesthesia induce a higher BG level. Linear regression analysis of BG and time of onset of diabetes in transplanted and non-transplanted BB-DP rats revealed no correlation (R(2) at 0.0075 and 0.0324 and p-values at 0.56 and 0.23 respectively). We were not able to identify any association or correlation between the induced temporary hyperglycaemia in 30-day-old BB-DP rats and later development of diabetes.
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ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-005-0185-z