Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin αv β3 in mucoepidermoid carcinoma and acinic cell adenocarcinoma of salivary gland origin

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 118; no. 3; pp. 320 - 329
• Main Authors: Fok, T.C., DDS, MSc, MD, Lapointe, H., DDS, PhD, Tuck, A.B., MD, PhD, Chambers, A.F., PhD, Jackson-Boeters, L., MLT, Daley, T.D., DDS, Darling, M.R., BChD, MChD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2014
• Subjects: Adenoma, Pleomorphic - pathology; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - metabolism; Carcinoma, Acinar Cell - pathology; Carcinoma, Mucoepidermoid - pathology; Child; Child, Preschool; Dentistry; Female; Humans; Hyaluronan Receptors - metabolism; Immunoenzyme Techniques; Integrin alphaVbeta3 - metabolism; Male; Middle Aged; Osteopontin - metabolism; Salivary Gland Neoplasms - pathology; Surgery
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2014.05.004

Objective Osteopontin (OPN) plays a role in tumor progression. This study aimed to determine the expression of OPN, CD44, and integrin αv β3 in pleomorphic adenoma (PA), acinic cell adenocarcinoma (ACA), and mucoepidermoid carcinoma (MEC). Study Design Immunohistochemistry was used to semiquantify the levels of expression of OPN and its receptors in normal salivary glands (NSG) (n = 20), PA (n = 20), ACA (n = 11), and MEC (n = 29). Results OPN expression was increased in ACA and MEC compared with PA and NSG (median scores, 6, 6, 4, and 4, respectively). CD44 expression was increased in ACA and reduced in MEC and PA compared with NSG (median scores, 8, 4, 3, and 5, respectively). Integrin αv β3 median scores were 5 in ACA, 1 in MEC, and 0 in PA and NSG. Conclusions OPN is expressed in salivary gland tumors and is at higher levels in ACA and MEC.