Effects of Sr2+, BO33−, and SiO32− on Differentiation of Human Dental Pulp Stem Cells into Odontoblast-Like Cells

• Published in: Biological trace element research Vol. 201; no. 12; pp. 5585 - 5600
• Main Authors: Miyano, Yuko, Mikami, Masato, Katsuragi, Hiroaki, Shinkai, Koichi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2023; Springer Nature B.V
• Subjects: Alizarin; Alkaline phosphatase; Biochemistry; Biomedical and Life Sciences; Biotechnology; Calcification; Cell culture; Cell differentiation; Cell proliferation; Culture; Culture media; Dental pulp; Dentin; Differentiation; Dspp protein; Gene expression; Immunocytochemistry; Ions; Life Sciences; Nestin; Nucleotide sequence; Nutrition; Oncology; PCR; Phosphatase; Polymerase chain reaction; Proliferation; Silicates; Stem cells; Strontium; Substrates; Strontium; Human dental pulp stem cells; Silicate; S-PRG; Borate; Odontogenic differentiation

This study aimed to clarify the effects of strontium (Sr 2+ ), borate (BO 3 3− ), and silicate (SiO 3 2− ) on cell proliferative capacity, the induction of differentiation into odontoblast-like cells (OLCs), and substrate formation of human dental pulp stem cells (hDPSCs). Sr 2+ , BO 3 3− , and SiO...