Histopathologic Spectrum of Connective Tissue Diseases Commonly Affecting the Skin

Connective tissue disorders (CTDs), also known as collagen vascular diseases, are a heterogeneous group of diseases with a common pathogenic mechanism: autoimmunity. Precise classification of CTDs requires clinical, serologic, and pathologic correlation and may be difficult because of overlapping cl...

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Bibliographic Details
Published inSurgical pathology clinics Vol. 10; no. 2; p. 477
Main Authors Laga, Alvaro C, Larson, Allison, Granter, Scott R
Format Journal Article
LanguageEnglish
Published United States 01.06.2017
Subjects
Autoimmune Diseases - pathology
Connective Tissue Diseases - immunology
Connective Tissue Diseases - pathology
Dermatomyositis - immunology
Dermatomyositis - pathology
Humans
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
Scleroderma, Localized - immunology
Scleroderma, Localized - pathology
Skin Diseases - immunology
Skin Diseases - pathology
Lupus
Histopathology
Dermatomyositis
Connective
Neutrophilic
Scleroderma
Patterns
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Summary:Connective tissue disorders (CTDs), also known as collagen vascular diseases, are a heterogeneous group of diseases with a common pathogenic mechanism: autoimmunity. Precise classification of CTDs requires clinical, serologic, and pathologic correlation and may be difficult because of overlapping clinical and histologic features. The main contribution of histopathology in the diagnosis of these disorders is to confirm, rule out, or alert clinicians to the possibility of CTD as a disease category, rather than producing definitive diagnoses of specific entities. This article discusses the histopathologic spectrum of 3 common rheumatologic skin disorders: lupus erythematosus, dermatomyositis, and morphea (localized scleroderma).
ISSN:1875-9157
DOI:10.1016/j.path.2017.01.012