New insights for integration of nano particle with microfluidic systems for sensor applications

• Published in: Biomedical microdevices Vol. 24; no. 1; p. 13
• Main Authors: Toppo, A. L., Jujjavarapu, S. E.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2022; Springer Nature B.V
• Subjects: Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biomolecules; Biophysics; Biosensors; Electron transfer; Engineering; Engineering Fluid Dynamics; Fluid flow; Gold; Immobilization; Metal Nanoparticles; Metal oxides; Microfluidics; Nanoparticles; Nanotechnology; Oxides; Physical properties; Reagents; Sensors; Silver; Substrates; Gold nanoparticles; Microfluidics; Sensor
• ISSN: 1387-2176; 1572-8781
• DOI: 10.1007/s10544-021-00598-5

A biosensor is a compact device, which utilizes biological derived recognition component, immobilized on a transducer to analyze an analyte. Nanoparticles with their unique chemical and physical properties are versatile in their applications to develop as sensors. Different nanoparticles play different roles in the sensing systems like metal and metal oxide nanoparticles. The application of Gold, Silver and Copper nanoparticles will be discussed in brief. The nanoparticles typically function as substrates for immobilization of biomolecules, as catalytic agent, electron transfer agent between electrode surface and the biomolecules, and as reactants. Microfluidic deals with manipulating very small volumes of fluids (micro and nanoliters). This miniaturized platform enhances control of flow conditions and mixing rate of fluids. The microfluidics improves the sensitivity of the analysis, and reduces the volumes of sample and reagent in the analysis. The review specifically aims at representing microfluidics-based sensors and nanoparticle based sensors. This review will also focus on probable merger of these two fields to take advantage of both the fields and this will help in pushing the boundaries of these fields further more.