Gene-gene interaction of ACE I/D, endothelial nitric oxide synthase 4 a/b and ApoE does not affect coronary artery disease severity

• Published in: Advances in clinical and experimental medicine : official organ Wroclaw Medical University Vol. 23; no. 2; pp. 215 - 223
• Main Authors: Matyar, Selçuk, Acartürk, Esmeray, Attila, Gülen, Ünal, Ilker, Soyer, Levent, Akpınar, Onur
• Format: Journal Article
• Language: English
• Published: Poland 01.03.2014
• Subjects: Adult; Aged; Apolipoproteins E - genetics; Coronary Artery Disease - genetics; Epistasis, Genetic; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III - genetics; Peptidyl-Dipeptidase A - genetics; Polymorphism, Genetic; Risk Factors; Severity of Illness Index
• ISSN: 1899-5276
• DOI: 10.17219/acem/37065

Previous studies have shown the impact of angiotensin converting enzyme (ACE) insertion/deletion (I/D), endothelial nitric oxide synthase (eNOS) polymorphisms and ApoE genotypes on coronary artery disease (CAD). The aim of this study is to investigate the relationship between the genetic polymorphisms and the severity of CAD and to evaluate their potential interactions. All patients underwent coronary angiography; coronary score (CS) and severity score (SS) were calculated for them. ACE I/D, eNOS and ApoE polymorphisms were detected by polymerase chain reaction (PCR). Neither CS nor SS showed a direct relationship with eNOS and ApoE genotypes. CS and SS were found to be high in patients carrying the ACE DD allele (p = 0.034 and p = 0.009). In the gene interactions, there was an increase in the SS only in patients with coexisting eNOS b/b genotype and ACE DD allele (p = 0.043). The interactions of the gene polymorphisms investigated don't play an important role in determining an individual's risk for the severity of CAD.