Comparison between pre- and post-contrast cardiac MRI cine images: the impact on ventricular volume and strain measurement

• Published in: The international journal of cardiovascular imaging Vol. 39; no. 5; pp. 1055 - 1064
• Main Authors: Tang, Lu, Diao, Kaiyue, Deng, Qiao, Wu, Xi, Peng, Pengfei, Yue, Xun, Wu, Tao, Cheng, Wei, Li, Yangjie, Zhou, Xiaoyue, Wetzl, Jens, Chen, Yucheng, Yue, Wenjun, Sun, Jiayu
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.05.2023; Springer Nature B.V
• Subjects: Amyloidosis; Cardiac Imaging; Cardiology; Cardiomyopathy; Contrast agents; Contrast Media; Ejection fraction; Heart; Heart Ventricles - diagnostic imaging; Humans; Image acquisition; Image contrast; Imaging; Injection; Magnetic resonance; Magnetic Resonance Imaging; Magnetic Resonance Imaging, Cine - methods; Medical imaging; Medicine; Medicine & Public Health; Original Paper; Parameters; Predictive Value of Tests; Prospective Studies; Radiology; Strain analysis; Strain measurement; Stroke Volume; Subgroups; Ventricle; Ventricular Function, Left; Ventricular Function, Right; Cine imaging; Cardiac magnetic resonance; Contrast agent; Ventricular volume; Strain
• ISSN: 1875-8312; 1569-5794; 1875-8312; 1573-0743
• DOI: 10.1007/s10554-023-02809-x

To explore whether contrast agent administration will affect ventricular volume and strain parameters measured on cardiac magnetic resonance cine images. This prospective study enrolled 88 patients, including 32 patients with cardiac amyloidosis (CA), 32 patients with hypertrophic cardiomyopathy (HCM), and 24 control participants, to perform steady-state free precession (SSFP)-cine imaging twice, respectively before and after contrast agent injection. Indexed left and right ventricular (LV and RV) volume and LV strain parameters (peak radial strain [PRS], peak circumferential strain [PCS], peak longitudinal strain [PLS]) were analyzed and compared between the pre- and post-contrast cine groups. Compared to the group of pre-contrast cine, the end-diastolic volume index (EDVi) and end-systolic volume index (ESVi) significantly increased in the group using post-contrast cine images (all p  < 0.05), especially in the right ventricle. After contrast injection, the right ventricular ejection fraction (RVEF) decreased significantly ( p  < 0.05), while the left ventricular ejection fraction (LVEF) only reduced for patients with HCM ( p  < 0.05). The PRS (37.1 ± 15.2 vs. 32.0 ± 15.4, p  < 0.001) and PCS (− 14.9 ± 4.3 vs. − 14.0 ± 4.1, p  < 0.001) derived from post-contrast cine images reduced significantly in all patients and this tendency remained in subgroup analysis except for PCS in the control group. The administration of a contrast agent may influence the measurements of ventricular volume and strain. Acquiring pre-contrast cine images were suggested for patients who required more accurate right ventricle evaluation or precise strain assessment.