Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis

The expression of angiopoietin (ANGPT) 1, ANGPT2, vascular endothelial growth factor (VEGF) A, VEGFB, VEGFC, VEGFD, and placental growth factor (PGF) is significantly higher in tumor tissues than in normal tissues in both unpaired and paired hepatocellular carcinoma (HCC) samples. ANGPT2, VEGFB, VEG...

Full description

Saved in:
Bibliographic Details
Published inWorld journal of gastroenterology : WJG Vol. 28; no. 30; pp. 4221 - 4226
Main Authors Miao, Yan-Dong, Tang, Xiao-Long, Wang, Jiang-Tao, Mi, Deng-Hai
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 14.08.2022
Subjects
Angiopoietin-2
Carcinoma, Hepatocellular
Computational Biology
Female
Humans
Letter to the Editor
Liver Neoplasms
Mitogen-Activated Protein Kinases
Placenta Growth Factor
Prognosis
Receptor Protein-Tyrosine Kinases
TOR Serine-Threonine Kinases
Vascular Endothelial Growth Factor A - metabolism
Bioinformatics analysis
Angiogenesis
Hepatocellular carcinoma
Marker
Pathway
Online AccessGet full text

Cover

More Information
Summary:The expression of angiopoietin (ANGPT) 1, ANGPT2, vascular endothelial growth factor (VEGF) A, VEGFB, VEGFC, VEGFD, and placental growth factor (PGF) is significantly higher in tumor tissues than in normal tissues in both unpaired and paired hepatocellular carcinoma (HCC) samples. ANGPT2, VEGFB, VEGFC, and PGF are primarily involved in regulating the activation of the epithelial-mesenchymal transition pathway; ANGPT1 is primarily involved in regulating the activation of the RAS/mitogen-activated protein kinase and receptor tyrosine kinase (RTK) pathways; VEGFA is engaged in regulating the RTK activation pathway; and VEGFD is mainly involved in regulating the activation of the tuberous sclerosis protein/mammalian target of rapamycin pathway. There is a significant difference in overall survival between HCC patients with high and low expression of ANGPT2, PGF, VEGFA, and VEGFD. Disease free survival (DFS) is significantly shorter in HCC patients with high ANGPT2, PGF, and VEGFA expression than in those with low ANGPT2, PGF, and VEGFA expression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Supported by the Special Plan for Condition Construction of Gansu Provincial Scientific Research Institutes, No. 20JR10RA432.
Corresponding author: Deng-Hai Mi, MD, Chief Doctor, Dean, Dean’s Office, Gansu Academy of Traditional Chinese Medicine, No. 418 Guazhou Road, Qilihe District, Lanzhou 730000, Gansu Province, China. mi.dh@outlook.com
Author contributions: Mi DH and Miao YD designed the research; Miao YD wrote this comment; Miao YD and Tang XL performed data analysis and prepared the tables and figures; Wang JT downloaded the data; Mi DH reviewed the manuscript; Miao YD and Tang XL contributed equally to this work; and all authors approved the final manuscript.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v28.i30.4221