The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice

• Published in: General physiology and biophysics Vol. 39; no. 5; p. 471
• Main Authors: Keser, Hatice, Doğramacı, Şeniz, Şahin, Elif, Sağlam, Neslihan, Erdem, Mehmet, Alver, Ahmet, Aydin-Abidin, Selcen
• Format: Journal Article
• Language: English
• Published: Slovakia 01.01.2020
• Subjects: Aging; Animals; Antioxidants - pharmacology; Behavior, Animal; Flavones - pharmacology; Lipid Peroxidation; Malondialdehyde; Mice; Neurodegenerative Diseases
• ISSN: 0231-5882
• DOI: 10.4149/gpb_2020022

7,8-Dihydroxyflavone (7,8-DHF) is a natural flavonoid compound that act as Trk-B agonist. 7,8-DHF is also a potent antioxidant. When applied systematically, 7,8-DHF can pass through blood-brain barrier and exhibit potential therapeutic effects in several animal models of neurodegenerative disorders. This study investigates the remedial effects of 7,8-DHF on behavioral impairments and biochemical changes associated with aging with a species emphasis on cortex. For this purpose three experimental groups were formed which are young control group, old group and old-DHF groups. 5 mg/kg 7,8-DHF was administered intraperitoneally to old-DHF group for 3 weeks. We assessed the hang wire and adhesive removal performances of mice. Also, oxidative stress, neuroinflammation and synaptic protein levels in the cortex were measured. We observed that chronic administration of 7,8-DHF improved behavioral performance of old mice. Besides, 7,8-DHF reversed MDA level which was increased in old control animals. However, 3 weeks application of 7,8-DHF failed to recover the levels of neuroinflammation markers (TNF-α and IL-6) and synaptic proteins (PSD-95 and Synaptophysin) which were reduced in old group. These findings demonstrate that improvement of age-dependent behavioral impairments and MDA levels by 7,8-DHF could be attributed to its antioxidant actions.