Enhance the Bioactivity and Osseointegration of the Polyethylene‐Terephthalate‐Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

• Published in: Advanced engineering materials Vol. 19; no. 5
• Main Authors: Yu, Bin, Pei, Peng, Yu, Baoqing, Li, Dejian, Zhang, Xu, Huang, Jianming, Ding, Huifeng, Chen, Shiyi, Zhu, Yufang
• Format: Journal Article
• Language: English
• Published: 01.05.2017
• ISSN: 1438-1656; 1527-2648
• DOI: 10.1002/adem.201600708

The objective of this study is to study the bioactivity and osseointegration of polyethylene‐terephthalate‐based artificial ligament coated with mesoporous bioactive glass (MBG) via polydopamine (PDA) in vitro and in vivo. In vitro, the OD value of MC3T3‐E1 cells on PDA‐MBG modified grafts is around 108% higher than that on pure PET after 5 days of culturing. The ALP activity of the PDA‐MBG group is about 1.5 times higher than that of the control group after 7 days of culturing. In the in vivo study, the results demonstrated that more newly formed bone tissue was found and the ultimate failure load increased in the PDA‐MBG coating group. In conclusion, PDA and MBG coating improves the surface bioactivity of the polyethylene‐terephthalate‐based artificial ligament and enhances the osseointegration within a bone tunnel. A straightforward method of PDA‐MBG modification on an artificial ligament is used to promote its biocompatibility and bioactivity in vitro and in vivo. And the modified PET artificial ligament is shown to be an efficient process for enhancing the bioactivity of the PET. The surface modification on PET‐based artificial ligament may be a novel applied for ligament reconstruction.