The Selection and Design of Topical and Transdermal Agents: A Review

One of the major problems in topical and transdermal drug delivery is the efficiency of the barrier property of the stratum corneum. Topical and transdermal agents were often originally designed as drugs to be given orally. In this paper a mechanistic evaluation of skin penetration shows that topica...

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Bibliographic Details
Published inThe Journal of investigative dermatology symposium proceedings Vol. 3; no. 2; pp. 131 - 135
Main Authors Hadgraft, Jonathan, John Pugh, W.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1998
Subjects
Administration, Cutaneous
Administration, Topical
Animals
Designer Drugs - administration & dosage
Designer Drugs - chemistry
Designer Drugs - pharmacokinetics
drug design
enhancers
Humans
Models, Molecular
skin
Skin - metabolism
topical drugs
transdermal
skin
topical drugs
enhancers
drug design
transdermal
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Summary:One of the major problems in topical and transdermal drug delivery is the efficiency of the barrier property of the stratum corneum. Topical and transdermal agents were often originally designed as drugs to be given orally. In this paper a mechanistic evaluation of skin penetration shows that topical and transdermal drugs should be designed using different strategies. The relative effects of basic physicochemical parameters are examined. An understanding, at a molecular level, of the permeation process will enable us to produce more effective topical agents and to extend the repertoire of transdermal drugs. Journal of Investigative Dermatology Symposium Proceedings 3:131–135, 1998
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1087-0024
1529-1774
DOI:10.1038/jidsymp.1998.27