Optimized Process and Bioreactor Characterization

The mass transfer coefficient (kL)and the value of the interfacial area (a) is used to characterize bioreactor systems for their oxygen transfer capability. The kLa value and the mixing time are amongst the most important performance indicators for bioreactors. Their calculation and modeling is extr...

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Bibliographic Details
Published inChemie ingenieur technik Vol. 91; no. 12; pp. 1719 - 1723
Main Author Maischberger, Thomas
Format Journal Article
LanguageEnglish
Published 01.12.2019
Subjects
Bioreactor characterization
Magnetic mixing technology
Oxygen transfer rate
Scale‐up process
Transfer coefficient
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Summary:The mass transfer coefficient (kL)and the value of the interfacial area (a) is used to characterize bioreactor systems for their oxygen transfer capability. The kLa value and the mixing time are amongst the most important performance indicators for bioreactors. Their calculation and modeling is extremely complex in highly aerated systems. This paper describes a new methodology for measuring the kLa value to accurately determine the coefficient. The valuable insights obtained allow for improved bioreactor characterization, thus, making it easier to meet regulatory requirements. Furthermore, examples outlining the benefits in the practical application of the new methodology are presented. One of the most relevant performance parameters is the volumetric mass transfer coefficient (kLa). This paper is revealing new insights achieved for large‐scale bioreactor characterization on the basis of a new methodology for measuring the kLa coefficient. Furthermore, examples are included, outlining the benefits in practical applications.
ISSN:0009-286X
1522-2640
DOI:10.1002/cite.201900134