Visible Light‐Initiated Catalyst‐Free One‐Pot, Multicomponent Construction of 5‐Substituted Indole Chromeno[2,3‐b]pyridines

A visible light‐initiated pseudo four‐component reaction of salicylaldehydes, indole and malononitrile in aqueous ethyl lactate is described. This pot, atomic and step economic (PASE) methodology provides a practical approach for the preparation of various 5‐substituted indole chromeno[2,3‐b]pyridin...

Full description

Saved in:
Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 361; no. 22; pp. 5182 - 5190
Main Authors Zhang, Mo, Chen, Meng‐Nan, Zhang, Zhan‐Hui
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 19.11.2019
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
chromeno[2,3-b]pyridines
ethyl lactate
green synthesis
indole
multi-component reaction
Physical Sciences
Science & Technology
visible light
multi-component reaction
3-COMPONENT SYNTHESIS
indole
CHROMENOPYRIDINES
visible light
IMIDAZOPYRIDINES
green synthesis
MEDIATED RADICAL ARYLDIFLUOROACETYLATION
GREEN
chromeno
FUNCTIONALIZATION
3-b]pyridines
METAL
INHIBITORS
ethyl lactate
EFFICIENT
DERIVATIVES
Online AccessGet full text

Cover

More Information
Summary:A visible light‐initiated pseudo four‐component reaction of salicylaldehydes, indole and malononitrile in aqueous ethyl lactate is described. This pot, atomic and step economic (PASE) methodology provides a practical approach for the preparation of various 5‐substituted indole chromeno[2,3‐b]pyridines from readily available starting materials at ambient temperature without any catalyst. High yields and excellent functional groups tolerance are observed.
Bibliography:These authors contributed equally to this work.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900994