Iodine-123 MIBG imaging in a generalized pancreatic polypeptide-gastrin-serotonin secreting tumor

The usefulness of radio-metaiodobenzylguanidine (MIBG), a specific radiopharmaceutical agent for scintigraphic imaging and treatment of phaeochromocytoma and neuroblastoma, has been extended to the location of carcinoid tumors. Scintigraphic evaluation with I-123 MIBG in a patient with a histologica...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 13; no. 5; p. 352
Main Authors Somers, G, Vanden Houte, K, Segers, O, Bossuyt, A
Format Journal Article
LanguageEnglish
Published United States 01.05.1988
Subjects
3-Iodobenzylguanidine
Adult
Apudoma - diagnostic imaging
Apudoma - metabolism
Female
Gastrins - metabolism
Humans
Iodine Radioisotopes
Iodobenzenes
Pancreatic Polypeptide - metabolism
Radionuclide Imaging
Serotonin - metabolism
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Summary:The usefulness of radio-metaiodobenzylguanidine (MIBG), a specific radiopharmaceutical agent for scintigraphic imaging and treatment of phaeochromocytoma and neuroblastoma, has been extended to the location of carcinoid tumors. Scintigraphic evaluation with I-123 MIBG in a patient with a histologically proven endocrine tumor (apudoma) of unknown origin with liver and bone metastases is reported. Elevated plasma hormone levels of gastrin, pancreatic polypeptide, and serotonin were found. Tumoral content of these hormones was immunocytochemically confirmed on liver biopsy. I-123 MIBG uptake could be seen in those areas of the liver with deficient lesions in the Tc-99m colloid image with a maximal uptake in a large mass at the level of the left liver lobe. No abnormal uptake could be observed at any other level, which was in contrast with autopsy findings of generalized metastatic disease.
ISSN:0363-9762
DOI:10.1097/00003072-198805000-00012