Inhibition of epinephrine-induced vasospasm with adrenoreceptor blockade in the rat cremaster muscle

This study demonstrates that intravenous epinephrine causes arterial vasospasm, but not venous constriction, in the microcirculation of the rat cremaster muscle. This effect can be blocked by a smooth muscle relaxant such as papaverine or an alpha receptor antagonist such as phentolamine. Circulatin...

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Bibliographic Details
Published inMicrosurgery Vol. 12; no. 1; p. 55
Main Authors Hartsock, L A, Seaber, A V, Urbaniak, J R
Format Journal Article
LanguageEnglish
Published United States 1991
Subjects
Animals
Arteries - drug effects
Arteries - physiology
Epinephrine - pharmacology
Male
Muscles - blood supply
Papaverine - pharmacology
Phentolamine - pharmacology
Rats
Receptors, Adrenergic - drug effects
Receptors, Adrenergic - physiology
Spasm - chemically induced
Spasm - physiopathology
Vascular Diseases - chemically induced
Vascular Diseases - physiopathology
Vasoconstriction - drug effects
Veins - drug effects
Veins - physiology
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Summary:This study demonstrates that intravenous epinephrine causes arterial vasospasm, but not venous constriction, in the microcirculation of the rat cremaster muscle. This effect can be blocked by a smooth muscle relaxant such as papaverine or an alpha receptor antagonist such as phentolamine. Circulating vasospastic agents such as epinephrine are important determinants of microcirculatory blood flow, and inhibition by pharmacologic means may enhance blood flow and survival in microvascular surgery.
ISSN:0738-1085
DOI:10.1002/micr.1920120111