Tissue-Specific Diversity and Functions of Conventional Dendritic Cells

Dendritic cells (DCs) are versatile controllers of immunity, which sense infection or tissue damage and, accordingly, initiate innate and adaptive effector responses. In recent years, it has become evident that DCs exist as an independent hematopoietic lineage comprising several developmentally dist...

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Bibliographic Details
Published inAdvances in immunology Vol. 134; pp. 89 - 135
Main Authors Pakalniškytė, Dalia, Schraml, Barbara U
Format Journal Article
LanguageEnglish
Published United States 2017
Subjects
Animals
Dendritic Cells
Humans
DC development
Dendritic cell
Inflammation
DC functions
DC subsets
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Summary:Dendritic cells (DCs) are versatile controllers of immunity, which sense infection or tissue damage and, accordingly, initiate innate and adaptive effector responses. In recent years, it has become evident that DCs exist as an independent hematopoietic lineage comprising several developmentally distinct and functionally specialized subsets that are strategically located in all organs to defend the organism against invading pathogens. Here, we review the diversity of DC subtypes found across tissues and discuss our current understanding of the tissue-specific functions of these cell types.
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ISSN:1557-8445
DOI:10.1016/bs.ai.2017.01.003