Recent advances in synthesis, metal complexes and biological evaluation of 2-aryl, 2-pyridyl and 2-pyrimidylbenzothiazoles as potential chemotherapeutics

• Published in: Inorganica Chimica Acta Vol. 502; p. 119302
• Main Authors: Elgemeie, Galal H., Azzam, Rasha A., Osman, Rokia R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.03.2020; Elsevier Science Ltd
• Subjects: 2-Aryl; 2-Pyridyl; 2-Pyrimidylbenzothiazoles; Aromatic compounds; Benzothiazole-based drugs; Benzothiazole-based medicinal chemistry; Coordination compounds; Drugs; Heterocyclic compounds; Medicinal chemistry; Metal complexes of benzothiazole derivatives; Organic chemistry; Pharmaceutical sciences; Pharmacology; Synthesis; Medicinal chemistry; 2-Aryl; Benzothiazole-based drugs; Benzothiazole-based medicinal chemistry; Metal complexes of benzothiazole derivatives; 2-Pyridyl; 2-Pyrimidylbenzothiazoles
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2019.119302

Benzothiazole compounds are the most used heterocyclic compounds in medicinal chemistry, a common and complementary feature of many pharmaceuticals. Benzothiazole derivatives and their metal complexes offers a variety of pharmacological properties, and a high degree of structural diversity that has proven important for the search for new therapeutics. This review provides a recent summary of research in the last 20 years on the synthesis, metal complexes and biological evaluation of 2-Aryl, 2-pyridyl and 2-pyrimidylbenzothiazoles as potential chemotherapeutics. [Display omitted] •Industrial pharmaceuticals.•First review article about synthesis and metal complexes of 2-aryl and 2-azinylbenzothiazoles.•Biological evaluation of 2-aryl, 2-pyridyl and 2-pyrimidylbenzothiazoles as potential chemotherapeutics. Benzothiazole compounds are the most used heterocyclic compounds in medicinal chemistry, a common and complementary feature of many pharmaceuticals. Benzothiazole derivatives and their metal complexes offer a variety of pharmacological properties, and a high degree of structural diversity that has proven important for the search for new therapeutics. The broad pharmacologic activities of benzothiazole compounds revealed that these compounds are important for future drugs. Recently, research on benzothiazole-based medicinal chemistry has become a rapidly evolving and increasingly active subject. In particular, many benzothiazole-based compounds as clinical drugs have been widely used in practice to treat various types of diseases with high therapeutic efficacy. This review provides a recent summary of research in the last 20 years on the synthesis, metal complexes and biological evaluation of 2-aryl, 2-pyridyl and 2-pyrimidylbenzothiazoles as potential chemotherapeutics. This review is useful for researchers in this field to provide them with new ideas to design new benzothiazole-based drugs.