Evaluation of mitomycin C in reducing postoperative adhesions in strabismus surgery

The aim of this study was to evaluate the efficacy of mitomycin C in reducing postoperative adhesions following strabismus surgery. This study was a prospective, single-center, interventional case series. We randomized 14 patients with restrictive strabismus to the mitomycin C group (7 patients) or...

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Bibliographic Details
Published inJournal of ocular pharmacology and therapeutics Vol. 21; no. 5; p. 406
Main Authors Chen, Po-Liang, Chen, Wan-Ying, Lu, Da-Wen
Format Journal Article
LanguageEnglish
Published United States 01.10.2005
Subjects
Adult
Aged
Double-Blind Method
Humans
Middle Aged
Mitomycin - therapeutic use
Postoperative Complications - prevention & control
Prospective Studies
Strabismus - surgery
Tissue Adhesions
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Summary:The aim of this study was to evaluate the efficacy of mitomycin C in reducing postoperative adhesions following strabismus surgery. This study was a prospective, single-center, interventional case series. We randomized 14 patients with restrictive strabismus to the mitomycin C group (7 patients) or to the control group (7 patients). We used mitomycin C intraoperatively for 5 min at a concentration of 0.2 mg/mL in the mitomycin group after adhesion release. We compared postoperative results using the forced duction test. Compared to the control group, the mitomycin C group exhibited a better range of passive duction at all postoperative follow-up times; however, mitomycin C did not completely eliminate the problem of postoperative adhesions. Patients receiving mitomycin C did not report any complications during this study. The intraoperative application of mitomycin C is a safe and effective adjunct to surgery in the treatment of restrictive strabismus.
ISSN:1080-7683
DOI:10.1089/jop.2005.21.406