Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract

(1) Background: Synchronous tumors are defined as tumors that occur at the same time, appearing within 2 months, according to the Surveillance Epidemiology and End Results Program, with a frequency of tertiary tumors of 0.5%. The purpose of this presentation is to report a case of three synchronous...

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Published inReports (MDPI) Vol. 7; no. 1; p. 14
Main Authors Boșoteanu, Mădălina, Vodă, Raluca Ioana, Balţǎtescu, Gabriela Izabela, Aşchie, Mariana, Nurla, Luana-Andreea, Orǎşanu, Cristian Ionuţ
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.02.2024
Subjects
Abdomen
Cancer
Case reports
Case studies
Cell division
Cervix
Comorbidity
Females
Genital cancer
Gynecology
Health aspects
Immunohistochemistry
Medical prognosis
Metastasis
Morphology
Mutation
Oncology, Experimental
Ovaries
ovary
p53
Patients
Physiological aspects
prognosis
Tumors
Uterus
Vagina
Romania
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Summary:(1) Background: Synchronous tumors are defined as tumors that occur at the same time, appearing within 2 months, according to the Surveillance Epidemiology and End Results Program, with a frequency of tertiary tumors of 0.5%. The purpose of this presentation is to report a case of three synchronous tumors of the female genital tract, given the fact that it represents a challenge both therapeutically and in demonstrating that the malignant lesions are completely different from each other. (2) Methods: We report the case of a 45 year-old patient diagnosed with three synchronous tumors developed in the genital tract: clear-cell ovarian carcinoma, uterine endometrioid adenocarcinoma, and cervical adenosquamous carcinoma. (3) Results: Total hysterectomy with bilateral anexectomy was performed and accompanied by a biopsy of the greater omentum. The evolution of the patient was favorable during chemotherapy, but she died two weeks after the completion of this treatment, from a cause secondary to the adverse effects determined by it, namely, severe thrombopenia which caused a massive lower digestive hemorrhage. (4) Conclusions: This case demonstrates the maximum importance of the involvement of adjuvant diagnostic techniques, especially when it comes to a diagnostic challenge with direct implications in the subsequent therapy of the patient.
ISSN:2571-841X
2571-841X
DOI:10.3390/reports7010014