The function of astrocytes and their role in neurological diseases

• Published in: The European journal of neuroscience Vol. 58; no. 9; pp. 3932 - 3961
• Main Authors: Yuan, Wen‐Qin, Huang, Wei‐Peng, Jiang, Yang‐Chao, Xu, Hao, Duan, Chong‐Shen, Chen, Nai‐Hong, Liu, Ying‐Jiao, Fu, Xiao‐Mei
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.11.2023
• Subjects: Alzheimer's disease; Aquaporin 4; Aquaporins; Astrocytes; Autophagy; Central nervous system; Connexin 43; Disease; Drug development; Energy metabolism; Huntington's disease; Huntingtons disease; Movement disorders; Multiple sclerosis; Neurodegenerative diseases; Neurological diseases; Neuromyelitis; Neurons; Parkinson's disease; Structure-function relationships; Tau protein; β-Amyloid
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/ejn.16160

Astrocytes have countless links with neurons. Previously, astrocytes were only considered a scaffold of neurons; in fact, astrocytes perform a variety of functions, including providing support for neuronal structures and energy metabolism, offering isolation and protection and influencing the formation, function and elimination of synapses. Because of these functions, astrocytes play an critical role in central nervous system (CNS) diseases. The regulation of the secretiory factors, receptors, channels and pathways of astrocytes can effectively inhibit the occurrence and development of CNS diseases, such as neuromyelitis optica (NMO), multiple sclerosis, Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease. The expression of aquaporin 4 in AS is directly related to NMO and indirectly involved in the clearance of Aβ and tau proteins in AD. Connexin 43 has a bidirectional effect on glutamate diffusion at different stages of stroke. Interestingly, astrocytes reduce the occurrence of PD through multiple effects such as secretion of related factors, mitochondrial autophagy and aquaporin 4. Therefore, this review is focused on the structure and function of astrocytes and the correlation between astrocytes and CNS diseases and drug treatment to explore the new functions of astrocytes with the astrocytes as the target. This, in turn, would provide a reference for the development of new drugs to protect neurons and promote the recovery of nerve function.