Killing of schistosomula by taurine chloramine and taurine bromamine

Eosinophils generate hypochlorous acid when stimulated with opsonized particles. The hypochlorous acid can react with beta-amino acids such as taurine to produce chloramines with a long lifetime. In the presence of bromide, eosinophils generate hypobromous acid which can react with taurine to genera...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of tropical medicine and hygiene Vol. 37; no. 1; p. 106
Main Authors Yazdanbakhsh, M, Eckmann, C M, Roos, D
Format Journal Article
LanguageEnglish
Published United States 01.07.1987
Subjects
Animals
Dose-Response Relationship, Drug
Schistosoma mansoni - drug effects
Taurine - analogs & derivatives
Taurine - pharmacology
Online AccessGet more information

Cover

More Information
Summary:Eosinophils generate hypochlorous acid when stimulated with opsonized particles. The hypochlorous acid can react with beta-amino acids such as taurine to produce chloramines with a long lifetime. In the presence of bromide, eosinophils generate hypobromous acid which can react with taurine to generate taurine bromamine. As taurine is abundantly present in leukocytes, eosinophils have the potential to generate taurine chloramine or taurine bromamine. With regard to the role of eosinophils in killing schistosomula, we have shown that both taurine chloramine and taurine bromamine in physiological concentrations are able to kill the schistosomula of Schistosoma mansoni.
ISSN:0002-9637
DOI:10.4269/ajtmh.1987.37.106