The influence of lovastatin on thrombomodulin gene expression in vascular endothelial cells--in vitro study

Statins reduce lipids concentration in blood. The latest investigations show they also improved the function of vascular endothelial cells (ECs). Thrombomodulin (TM) is particularly important marker of ECs activity. We investigated the in vitro effect of lovastatin on the expression level of TM gene...

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Published inFolia histochemica et cytobiologica Vol. 47; no. 1; pp. 43 - 45
Main Authors Góralczyk, Krzysztof, Soszyńska, Krystyna, Haus, Olga, Bielis, Robert, Rość, Danuta
Format Journal Article
LanguageEnglish
Published Poland Wydawnictwo Via Medica 01.01.2009
Subjects
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Gene Expression Regulation - drug effects
Humans
Lovastatin - pharmacology
Thrombomodulin - genetics
Thrombomodulin - metabolism
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Summary:Statins reduce lipids concentration in blood. The latest investigations show they also improved the function of vascular endothelial cells (ECs). Thrombomodulin (TM) is particularly important marker of ECs activity. We investigated the in vitro effect of lovastatin on the expression level of TM gene. ECs were incubated for 24 h in culture medium including lovastatin in 3 concentrations: 0.1, 1.0, 10.0 mol/l. The mRNA level of TM increased in correlation with rising concentrations of lovastatin to 600 % vs. control group. TM is essential antithrombotic factor in endothelial cells. Lovastatin significantly raises thrombomodulin gene expression. It is important characteristics of this medicine, which prevents cardiovascular events.
Bibliography:ObjectType-Article-1
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ISSN:0239-8508
1897-5631
DOI:10.2478/v10042-009-0012-4