A comparative study of some combined treatment regimens in acute toxoplasmosis in mice

The effectiveness of five treatment regimens was compared to mice during acute and late infection with Toxoplasma gondii. Parasitic cure rates, as judged by failure of brain tissue from surviving mice to produce infection when inoculated into clean mice, were as follows: pyrimethamine + sulfamethoxy...

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Bibliographic Details
Published inThe American journal of tropical medicine and hygiene Vol. 27; no. 4; p. 747
Main Authors Thiermann, E, Apt, W, Atias, A, Lorca, M, Olguín, J
Format Journal Article
LanguageEnglish
Published United States 01.07.1978
Subjects
Acute Disease
Animals
Clindamycin - administration & dosage
Drug Therapy, Combination
Humans
Leucomycins - administration & dosage
Mice
Pyrimethamine - administration & dosage
Sulfamethoxazole - administration & dosage
Sulfamethoxypyridazine - administration & dosage
Toxoplasmosis, Animal - drug therapy
Trimethoprim - administration & dosage
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Summary:The effectiveness of five treatment regimens was compared to mice during acute and late infection with Toxoplasma gondii. Parasitic cure rates, as judged by failure of brain tissue from surviving mice to produce infection when inoculated into clean mice, were as follows: pyrimethamine + sulfamethoxypyridazine, 92%; clindamycin + sulfamethoxypyridazine, 75%; spiramycin + sulfamethoxypyridazine, 16.7%; trimethoprim + sulfamethoxypryridazine alone, 0%. Pyrimethamine + sulfamethoxypyridazine was the most effective combination against acute toxoplasmosis in mice.
ISSN:0002-9637
DOI:10.4269/ajtmh.1978.27.747